Click on the papers for abstract and links to pdf/fulltext.

Comprehensive structure and functional adaptations of the yeast nuclear pore complex

Akey, Singh, Ouch, Echeverria et al. Cell 2022

A viral genome packaging ring-ATPase is a flexibly coordinated pentamer

Li, Singh et al. Nature Comm. 2021

Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA

Poddar et al. Nature Comm. 2021

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

Yu et al. Science 2021

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Lu, Ye et al. Nature Comm. 2021

Real-time observation of Cas9 postcatalytic domain motions

Wang et al. PNAS 2021

Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography

Wagner, Castillon et al. Nature Protocols 2021

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

Okafor, Singh, Wang et al. Nature Comm. 2021

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)

Singh et al. PNAS. 2018

Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis

Singh et al. Nature Struct Mol Bio. 2018

Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches

Singh et al. ACS Chemical Biology 2018

The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays

Hua et al. Biochemistry 2018

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9

Singh et al. Nature Communications 2016

Determination of in vivo target search kinetics of regulatory noncoding RNA

Fei et al. Science 2015

An Improved Surface Passivation Method for Single-Molecule Studies

Hua et al. Nature Methods 2014

Protein stability and folding kinetics in the nucleus and endoplasmic reticulum of eucaryotic cells

Dhar et al. Biophys J. 2011